The Trianni Mouse®  is a transgenic antibody discovery platform that expresses the entire human antibody repertoire in a single organism. In this mouse, the murine immunoglobulin heavy, kappa and lambda chain loci are replaced by corresponding transgenic loci, in which human exons are embedded in murine control regions. As a result, upon antigen challenge, the mice produce human antibody repertoires, yet wild-type mouse antibody responses.