A Powerful Platform for the Isolation of Fully-human Monoclonal Antibodies

Genetically engineered mice now act as robust engines for the generation of diverse repertoires of affinity-matured, fully-human variable regions with intrinsic drug-like properties necessary for successful development including high potency, specificity, manufacturability, solubility and low risk of immunogenicity. Few existing or contemplated human transgenic mouse platforms express a full 
human antibody repertoire. Our lead technology, The Trianni Mouse is the only one to do so in a single organism.