The Trianni Mouse

about

An advanced transgenic platform for the facile isolation of fully human monoclonal antibodies

  • Endogenous V, D and J gene segments deleted and positionally substituted with optimized cassette
  • Chimeric gene segments (human open reading frames paired with mouse regulatory regions)
  • Chimeric antibodies (human Vs with mouse Cs)
  • Precise genetic integration enables rapid production of next-gen variants