Advantages

advantages4

Key Advantages of The Trianni Mouse

Engineered versions of all three antibody genetic loci (Heavy, Kappa and Lambda)• Engineered versions of all three antibody
genetic loci – Heavy, Kappa and Lambda

  •  Novel chimeric antibody gene segments, each comprised of human coding sequences combined with mouse regulatory genomic sequences
  • Expression of a full repertoire of human heavy- and light-chain variable domains
  • Multiple enhancements to antibody gene segments
  • Retention of all mouse constant domains
  • Two light chain loci capable of expressing both Kappa and Lambda light chains
  • Normal genomic rearrangement in developing B cells leading to normal B cell development
  • Normal immune responses
  • Robust somatic hypermutation and class switching