Advantages

Key Advantages of The Trianni Mouse

Engineered versions of all three antibody genetic loci (Heavy, Kappa and Lambda)• Engineered versions of all three antibody
genetic loci – Heavy, Kappa and Lambda

•  Novel chimeric antibody gene segments, each comprised of human coding sequences combined with mouse regulatory genomic sequences
• Expression of a full repertoire of human heavy- and light-chain variable domains
• Multiple enhancements to antibody gene segments
• Retention of all mouse constant domains
• Two light chain loci capable of expressing both Kappa and Lambda light chains
• Normal genomic rearrangement in developing B cells leading to normal B cell development
• Normal immune responses
• Robust somatic hypermutation and class switching