Key Advantages of The Trianni Mouse
Engineered versions of all three antibody genetic loci (Heavy, Kappa and Lambda)• Engineered versions of all three antibody
genetic loci – Heavy, Kappa and Lambda
- Novel chimeric antibody gene segments, each comprised of human coding sequences combined with mouse regulatory genomic sequences
- Expression of a full repertoire of human heavy- and light-chain variable domains
- Multiple enhancements to antibody gene segments
- Retention of all mouse constant domains
- Two light chain loci capable of expressing both Kappa and Lambda light chains
- Normal genomic rearrangement in developing B cells leading to normal B cell development
- Normal immune responses
- Robust somatic hypermutation and class switching
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